GLP-1 Receptor Agonist (Oral)
Oral Semaglutide
Brand name: Rybelsus
Average weight loss
~10%
of body weight
What is Oral Semaglutide?
Oral semaglutide (Rybelsus) contains the same active ingredient as injectable Wegovy/Ozempic but in a convenient daily pill form. It uses a special absorption enhancer (SNAC) to allow the peptide to be absorbed through the stomach lining.
This is an excellent option for patients who prefer not to self-inject or are needle-averse, while still benefiting from the proven GLP-1 mechanism of action.
How to take it
- 1Take first thing in the morning on an empty stomach
- 2Swallow with no more than 4 oz (120 mL) of plain water
- 3Wait at least 30 minutes before eating, drinking, or taking other medications
- 4Do not crush, chew, or split the tablet
Dosing schedule
Month 13 mg daily
Month 27 mg daily
Month 3+14 mg daily (maintenance)
Common side effects
NauseaDiarrheaDecreased appetiteVomitingConstipationAbdominal painHeartburn